The sysinternal guys released a new tool: Process Monitor.
Process Monitor is an advanced monitoring tool for Windows that shows real-time file system, Registry and process/thread activity. It combines the features of two legacy Sysinternals utilities, Filemon and Regmon, and adds an extensive list of enhancements including rich and non-destructive filtering, comprehensive event properties such session IDs and user names, reliable process information, full thread stacks with integrated symbol support for each operation, simultaneous logging to a file, and much more. Its uniquely powerful features will make Process Monitor a core utility in your system troubleshooting and malware hunting toolkit.
Process Monitor runs on Windows 2000 SP4 with Update Rollup 1, Windows XP SP2, Windows Server 2003, and Windows Vista as well as x64 versions of Windows XP, Windows Server 2003 and Windows Vista.
Check it out here